ABOUT INTEGRATIVE STRUCTURAL BIOLOGY

This thematic promotes work that enables the scientific community to use and combine a range of structural biology methods.  With the new possibilities offered by MAX IV and ESS, and with rapid progress in the fields of macromolecular crystallography, Cryo-EM, small angle scattering and the use of XFELs, the scientists benefiting from these methods do not always know what the different possibilities are and how to best combine data from complementary structural biology techniques.  There is an urgent need for knowledge in how to exploit combined data from neutrons and X-rays to answer completely new research questions regarding macromolecular structure and function.

HAPPENING IN INTEGRATIVE STRUCTURAL BIOLOGY

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CORE GROUP

WORKING GROUPS FOR INTEGRATIVE STRUCTURAL BIOLOGY

ISB Work Group 1

Biocompute

The Biocompute Working Group seeks to addess several fundamental issues such as:

  • Novel and refined program packages are needed for new MX/neutron technologies (XFEL, neutron data from spallation sources, and much more)
  • Integration of state-of-the-art Applied Maths in existing software
  • Appropriate researcher training to understand the processes linking data with results
  • A need to learn how to utilise HPC much more efficiently than we do today
  • A need to see, learn and integrate the potential of machine learning & AI techniques in our analysis

We focus our activities toward project-oriented SB users with complex scientific questions (multimodular, dynamics, size, time-resolved and more), experimental infrastructure staff/scientists, HPC compute infrastructure staff/scientists and user-access platforms, and applied mathematicians and programmers

ISB Work Group 2

INtrinsically Disordered Proteins

The goal of the Working Group on Intrinsically Disordered Proteins (IDPs) is to form a strategic hub and create a venue for IDP research in the Nordic countries. The aim is to bring together the research community in IDP-research across the disciplines and emphasize the possibilities of using neutron and X-ray scattering in combination with other experimental techniques and computer simulations to obtain a molecular understanding of the systems. The mission will be fulfilled by for example hosting international conferences and thematic workshops regarding IDPs, which covers (i) IDPs in solution, (ii) intermolecular interactions between IDPs to surfaces and membranes, and (iii) liquid-liquid phase separation. The first conference is planned to be held in the autumn 2019.