Prof. Christine Ziegler

Prof. Christine Ziegler

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Integrative Structural Biology Core Group Member, External LINXS Fellow

My group focuses on the structure and function of membrane proteins and macromolecular complexes, which are involved in stress-regulated and stress-activated transport processes across the membrane.

Besides X-ray crystallography, SAXS, and electron microscopy we apply a variety of different biophysical and biochemical techniques to characterize the function of membrane proteins in order to elucidate their molecular mechanism.

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The main research interests of my group concern the study of macromolecular systems using physical techniques. Neutron and X-ray scattering techniques at the Institut Laue Langevin (ILL) and the European Synchrotron Radiation Facility (ESRF) are central to this. Current project work includes structural studies of DNA, DNA-drug interactions and DNA-protein complexes, self assembling systems of synthetic and biological origin.

We are also deeply involved in methodological developments for neutron and X-ray scattering. The Integrated Macromolecular Structure Research Group is based at the Partnership for Structural Biology (PSB) in Grenoble, France, where a wide variety of techniques are available to complement the capabilities of the Grenoble central facility infrastructures. For further details, see (http://www.ill.fr/deuteration).