When: Wednesday April 5, 10.30 - 12.00
Where: at LINXS (Scheelvägen 19, Lund), with digital participation possibility (Zoom)
Title: Colloidal lipid self-assembly materials in nanomedicine
Speaker: Calum Drummond Deputy Vice-Chancellor Research and Innovation and a Vice President of RMIT University
Bio:
Professor Calum J. Drummond is the Deputy Vice-Chancellor Research and Innovation and a Vice President of RMIT University. He is an active research professor and has published over 250 articles and patents in the area of advanced materials. He has a strong interest and passion for the commercialisation of research. He has a PhD and DSc from The University of Melbourne. Professor Drummond joined RMIT in 2014 from the Australian national science agency, CSIRO, where he was Group Executive for Manufacturing, Materials and Minerals. Earlier, he was Chief of CSIRO Materials Science and Engineering and CSIRO Industrial Physics. He is a Fellow of the Australian Institute of Company Directors (FAICD), the Australian Academy of Technological Sciences and Engineering (FTSE), and the National (USA) Academy of Inventors (FNAI). He has been an Australian Research Council (ARC) Federation Fellow and ARC Queen Elizabeth II Fellow, and is currently an ARC Advisory Council Member. Professor Drummond was the inaugural Vice President Research at CAP-XX, initially an Intel portfolio company, which listed on the London Stock Exchange (AIM). The World Economic Forum designated CAP-XX as a Global Technology Pioneer, and CAP-XX also received the Frost and Sullivan (USA) Nanotechnology-Enabled Energy Devices Technology Innovation of the Year Award.
Amongst many awards, Professor Drummond is a recipient of the Victoria Prize for Science and Innovation in Physical Sciences, and the Ian Wark and Le Fevre Medals from the Australian Academy of Science. He has received 8 national awards from the Royal Australian Chemical Institute (RACI), and CSIRO’s 3 highest awards, viz., CSIRO Fellow, CSIRO Medal for Outstanding Research Achievement, and CSIRO Medal for Business Excellence. He has a Lifetime Achievement Award and Honorary Lifetime Alumni Membership for Contributions to Industry-Research Collaboration from Cooperative Research Australia. Professor Drummond is also the recipient of a Fulbright Senior Scholarship from the US Department of State, and a Distinguished Lecturer Award of the Chemical Society of Japan.
Professor Drummond is an Officer of the Order of Australia (AO) recognising his contributions to chemistry and materials science research, commercialisation initiatives, and mentoring.
Abstract:
Colloidal (nanoparticulate) lipid nanocarriers of bioactive agents are receiving increased attention from the research community. In part, this significant interest is a direct consequence of Moderna and BioNTech/Pfizer developing mRNA-based vaccines for COVID-19, where lipid nanoparticles (LNPs) deliver the mRNA to the desired cell target. In addition to mRNA, these LNPs are composed of an ionisable lipid for complexing the nucleic acid, PEGylated lipid to sterically stabilise the NP, and structural “helper” lipids. A microfluidic formulation process is generally used to produce the LNPs.
More broadly, harnessing the potential of lipid nanocarriers to deliver bioactive agents holds great promise in treating and preventing a range of diseases. In this presentation, the preparation of colloidal lipid nanocarriers with lyotropic liquid crystalline internal mesostructure will be described. The focus will be on cubosomes and hexosomes.
The self-assembled nanostructures of LNPs are closely related to their interactions with cells and biological function. LNP-cell interaction will be outlined. The behaviour of ionisable lipids and novel steric stabilisers residing in these LNPs can be used to control structure, stability, and functional performance. Examples of the bioactive performance of self-assembled lipid nanocarriers of antifungal and antibacterial drugs, vaccines, and chemotherapeutics will be discussed.
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