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Mini-symposium: Neutron scattering in drug discovery, design, and formulation – IPDD theme


Sign up for a 2-day mini-symposium on neutron diffraction in drug discovery, design and formulation (7-8 May), followed by an afternoon tour at European Spallation Source in Lund (8 May)!

Title: Neutron scattering in drug discovery, design, and formulation

When: 7–8 May, 2024, including buffet dinner at LINXS (7/5) and a visit to European Spallation Source (8/5)

Where: Workshop room on the 5th floor of LINXS (Scheelevägen 19, Lund) or online via Zoom. Physical participation is encouraged!

Fees and registration information:

Please indicate in the registration if you would like to join the dinner in the evening and the guided tour at ESS.

  • Physical participation: 700 SEK

  • Online participation: 350 SEK

EXTENDED DEADLINE! Please note that the registration deadline for the tour at ESS is 2/5.

Abstracts: There will be an opportunity to submit an abstract for a contributed talk. If you wish to have a talk, please send your abstract to raminta.venskutonyte@med.lu.se after completing the registration.

Walking Tour at European Spallation Source: Please note that there is a limited number of spots available for a walking tour of the experimental halls and deuteration labs. All those interested need to register by 2/5. Participants need to bring a picture ID for security purposes and also wear long trousers and closed shoes since we will be entering an active construction site.


Invited speakers


Program

May 7

12:00–13:00 Lunch and registration

13:00–13:10 Welcome and introduction

13:10–13:50 “Investigating structure and performance in lipid nanocarriers”, Hanna Barriga, Karolinska Institute, Stockholm

13:50–14:20 "Update on the Large-Scale Structures Instruments at ESS”, Thomas Arnold, European Spallation Source, Sweden

14:20–15:00  "Studies of hydrogen bonding in galectin-3 using neutron crystallography can aid drug design", Derek Logan, Lund University, Sweden

15:00–15:20 Coffee break

15:20–15:50 “DEMAX: the deuteration and crystallization support platform at ESS”, Zoë Fisher, European Spallation Source, Sweden

15:50–16:30 “Interactions at the lipid-aqueous interface – a key factor for drug delivery using lipid nanoparticles”, Tommy Nylander, Lund University

16:30–17:10 “The catalytic mechanism of the SARS CoV 2 Macrodomain and how to inhibit it”, James Fraser (via Zoom), UCSF School of Pharmacy, USA

17:30– Mingle followed by a buffet dinner at LINXS

May 8

08:45–09:15 Arrival and coffee/buns

09:15–09:55 “Structural investigation of lipid nanoparticle is key to improve mRNA delivery“, Federica Sebastiani, University of Copenhagen, Denmark

09:55–10:35 “A new view into the mechanism of apoptosis-regulating Bcl-2 proteins in mitochondrial membrane mimics using neutron reflection”, Hanna Wacklin-Knecht, European Spallation Source, Sweden

10:35–10:50 Coffee break

10:50–11:30 “How deep is your drug-depth-resolved drug interactions with lipid bilayers using neutrons”, Nicolo Paracini (via Zoom), Institut Laue-Langevin, France

11:30–12:00 Contributed talk

12:00–12:10 Final remarks and practicalities for the ESS visit

12:10–13:00 Lunch at LINXS

Travel to ESS

13:30–15:00 Safety instructions and tour at ESS

15:00–16:00 Coffee and Q&A


Organisers

The main organiser of the event is Raminta Venskutonyte raminta.venskutonyte@med.lu.se

For practical questions about the workshop, please contact josefin.martell@linxs.lu.se


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